Scientist, Genetic Assays

Overview

In this role you will design and execute phase-appropriate biochemical and molecular assays to enable PK/PD analyses, integrating genetic, bioanalytical, and translational work to support Moderna’s clinical programs. You will build and validate mRNA-based bioanalytical capabilities, collaborating with cross-functional teams and CRO partners while embracing digital tools to streamline workflows. You will work onsite at Oxford and contribute to a fast-moving pipeline at the intersection of translational science and bioanalysis, shaping assay strategies for clinical development.

Pay / Benefits

• competitive healthcare
• well-being resources
• family building benefits
• paid time off
• sabbatical and global recharge days
• discretionary year-end shutdown

Responsibilities

• Design and perform phase-appropriate biochemical and molecular assays (DNA/RNA isolation, qPCR, ddPCR, RNA sequencing, MSD, ELISA, immunoblotting) for PK/PD analysis
• Develop assays aligned with program timelines and ensure qualification/validation within GcLP for clinical use
• Troubleshoot technical issues with internal teams and CRO partners to maintain data quality
• Review raw data and validation reports to ensure regulatory and scientific quality standards are met
• Establish internal and external mRNA-based bioanalytical capability and support method development for Moderna’s portfolio
• Support procurement and qualification of analytical equipment and maintain SOPs and reagents control
• Stay current with GLP/GCP guidelines and internal SOPs relevant to clinical bioanalysis
• Collaborate with Clinical Operations and Sample Management to define sample workflows and laboratory manuals
• Apply RT-PCR, ddPCR, RNA sequencing and related methods in preclinical/clinical assays
• Balance external scientific developments with Moderna’s bioanalytical work in the ASO field
• Communicate complex concepts effectively within a matrix environment
• Leverage LIMS, eLNB and laboratory automation where relevant
• Explore use of Generative AI-enabled tools to enhance scientific workflows and data handling

Key requirements

• Ph.D. in genetic assays or related fields with 5+ years industry biotech/pharma experience OR B.S./M.S. with 7+ years bioanalytical and GcLP/GLP experience
• Expert knowledge of RT-PCR, ddPCR, RNA sequencing and related assay methods
• Working knowledge of translational literature and ASO landscape
• Understanding of GcLP requirements and current regulatory trends in analytical science
• Experience with LIMS and eLNB is a plus; automation experience a plus
• Strong communication skills and ability to work in a matrix environment
• Knowledge of GLP and GCP guidance and clinical trial conduct

• Effective scientific communication
• Collaborative mindset
• Problem-solving under regulatory constraints
• RT-PCR
• ddPCR
• RNA sequencing

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