Technical Specialist – Bioanalysis & Biotransformation

Overview

In this role you will act as the technical expert for metabolite identification and structure elucidation using high-resolution MS. You will conduct analytical work across regulatory and non-regulatory studies, spanning in vitro, in vivo, clinical, and biological/ environmental fate projects. You’ll develop LC-MS methods, interpret data, and contribute to scientific reporting, trainings, and client discussions. The role includes collaboration with Study Directors, mentoring peers, and leading process improvements, within a global Metabolism team.

Pay / Benefits

• Collaborative culture
• Career development opportunities
• Global organisation
• Opportunities to work on diverse programs
• Focus on scientific excellence

Responsibilities

• Act as a technical expert in metabolite identification and structure elucidation using high-resolution mass spectrometry
• Conduct analytical and metabolite identification work for regulatory and non-regulatory studies in line with study plans and timelines
• Support studies across in vitro, in vivo, clinical, large molecule/biological, and environmental fate programmes
• Develop and optimise LC-MS/MS chromatographic methods within the group and across the wider Metabolism Department
• Interpret analytical data and prepare accurate scientific updates, study documentation, and report contributions
• Work closely with Study Directors and Analytical Project Managers to ensure successful delivery of client projects
• Contribute scientifically to client communications and discussions, where appropriate
• Develop training materials and deliver training in your area of specialism
• Mentor and support colleagues by sharing technical knowledge and best practice
• Lead process improvement and new service development projects within your specialist area
• Maintain responsibility for assigned equipment, software, and laboratory areas
• Address relevant findings arising from QA audits and process inspections
• Maintain and write SOPs as required
• Help raise the external profile of the department through publications, posters, presentations, and participation in expert groups
• Ensure all work is performed in accordance with Health & Safety requirements, GxP standards, study plans, SOPs, and company procedures

Key requirements

• PhD, MSc or BSc (Hons) in Chemistry, Biochemistry, or a related scientific discipline
• Experience in metabolite identification within a CRO, pharmaceutical, or agrochemical environment
• Strong experience in chromatographic method development
• Experience in a GLP or regulated laboratory environment (beneficial)
• Proficient in high-resolution MS platforms (Waters Vion, Thermo Q Exactive)
• Experience with Xcalibur, Waters UNIFI, and Compound Discoverer
• Good knowledge of metabolism and metabolic reactions
• Strong LC-MS/MS data interpretation and structure elucidation skills
• Excellent data interpretation, reporting, and presentation skills
• Confident written and verbal communication for client discussions
• Strong organizational, problem-solving, prioritization, and scheduling skills
• Experience coaching or mentoring colleagues
• Good project management skills
• Proficient with Microsoft Office
• Conscientious, meticulous, and able to handle multiple priorities under tight deadlines
• Flexible, proactive, and willing to support changing study requirements including occasional extended hours or weekend work

• Excellent communication
• Mentoring and coaching
• Strong organisation and prioritisation
• High-resolution mass spectrometry
• LC-MS/MS method development
• Metabolite identification and structure elucidation

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