Director, GDC Head of ADC Oncology Chemistry

Overview

In this strategic leadership role, you steer the chemistry strategy for antibody-drug conjugate and vectorized drug conjugate programs in oncology. You will lead a team of medicinal chemists, shape portfolio priorities, and foster cross-functional partnerships to translate science into patient-focused therapies. You’ll drive breakthrough chemistry approaches, manage complex programs from discovery to development milestones, and advocate an inclusive, innovative culture. This is a mission-driven opportunity to influence next-generation oncology modalities at Novartis.

Pay / Benefits

• flexible and hybrid working options
• minimum 14 weeks paid parental leave
• insurance plans
• retirement plans
• wellbeing resources
• global recognition programs

Responsibilities

• Lead medicinal chemistry strategy for ADC and vectorized drug conjugate programs across the oncology portfolio
• Guide project teams from exploratory research to candidate nomination
• Build, mentor and develop a high-performing team of medicinal chemists
• Partner with biology, biotherapeutics, PK, safety, and process chemistry to advance programs
• Shape portfolio strategy, prioritization and resourcing aligned with oncology goals
• Identify emerging technologies, external collaborations and opportunities to strengthen the discovery portfolio
• Foster an innovative, inclusive and collaborative environment amid complexity and change

Key requirements

• Doctoral degree in Organic Chemistry, Medicinal Chemistry or closely related discipline
• Minimum 12 years of pharma/biotech R&D experience with significant leadership experience
• Proven success advancing oncology drug discovery toward clinical development
• Deep knowledge of antibody-drug conjugates and vectorized drug conjugates
• Broad understanding of drug discovery disciplines including PK, toxicology and pharmacology
• Demonstrated ability to lead multidisciplinary teams, influence across functions, and translate science into strategic decisions

• Strategic leadership
• Cross-functional collaboration
• People development
• Antibody-drug conjugates (ADCs) and vectorized drug conjugates
• Medicinal chemistry and lead optimization
• Structure-activity relationships (SAR)

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