Research Scientist I or II, Oligonucleotide Chemistry

Overview

As a Research Scientist in Oligonucleotide Chemistry, you will synthesize, optimize, and characterize therapeutic oligonucleotides, working hands-on with automated synthesizers. You will collaborate across discovery and development teams to advance RNA-based therapeutics toward patients. You’ll develop methods to improve performance and reproducibility while upholding high-quality lab practices. This Cambridge-based role offers a meaningful opportunity to contribute to transformative therapies in the xRNA program.

Pay / Benefits

• flexible and hybrid working options
• minimum 14 weeks paid parental leave
• insurance plans
• retirement plans
• wellbeing resources
• global recognition programs

Responsibilities

• Perform solid-phase synthesis of oligonucleotides on automated DNA/RNA synthesizers
• Purify, desalt, and characterize oligos using chromatography and mass spectrometry
• Develop and optimize synthesis, purification, and analytical methods
• Operate, maintain, and troubleshoot lab instruments for oligonucleotide production and analysis
• Prepare and maintain SOPs for consistent laboratory practices
• Document experimental results using electronic lab notebook systems
• Collaborate effectively within a fast-paced, cross-functional research environment

Key requirements

• Bachelor of Science or Master of Science in Chemistry or related discipline
• 1–3 years of laboratory experience in research settings
• Hands-on experience with automated solid-phase synthesizers and oligonucleotide workflows
• Proficiency in purification, characterization, and analysis of oligonucleotides via chromatography and MS
• Understanding of RNA therapeutics and their biological applications
• Strong collaboration, adaptability, and self-motivation in a scientific context

• Collaboration
• Adaptability
• Self-motivation
• Automated solid-phase synthesizers
• Oligonucleotide synthesis workflows
• Chromatography

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