ZAP-KHNYN Antiviral Researcher

Crick Institute invites applications for a 2027 PhD project focused on the zinc finger antiviral protein (ZAP) and its cofactors KHNYN and Trim25. The project will explore how ZAP restricts a range of viruses, including retroviruses and SARS-CoV-2, using structural, biochemical and enzymological approaches.

The student will purify ZAP, KHNYN and Trim25 domains and full-length proteins, analyse RNA-binding and degradation, and determine cryo-EM structures of ZAP-KHNYN complexes to elucidate

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